Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "experimental-drug"
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1. Rise of the Planet of the Apes (2011)
PG-13 | 105 min | Action, Drama, Sci-Fi
A substance designed to help the brain repair itself gives advanced intelligence to a chimpanzee who leads an ape uprising.
Director: Rupert Wyatt | Stars: James Franco, Andy Serkis, Freida Pinto, Karin Konoval
Votes: 558,722 | Gross: $176.76M
2. Lucy (I) (2014)
R | 89 min | Action, Sci-Fi, Thriller
A woman, accidentally caught in a dark deal, turns the tables on her captors and transforms into a merciless warrior evolved beyond human logic.
Director: Luc Besson | Stars: Scarlett Johansson, Morgan Freeman, Choi Min-sik, Amr Waked
Votes: 534,148 | Gross: $126.66M
3. Old (2021)
PG-13 | 108 min | Drama, Horror, Mystery
A vacationing family discovers that the secluded beach where they're relaxing for a few hours is somehow causing them to age rapidly, reducing their entire lives into a single day.
Director: M. Night Shyamalan | Stars: Gael García Bernal, Vicky Krieps, Rufus Sewell, Alex Wolff
Votes: 160,518 | Gross: $48.28M
4. Limitless (I) (2011)
PG-13 | 105 min | Sci-Fi, Thriller
A mysterious pill that enables the user to access 100% of his brain's abilities transforms a struggling writer into a financial wizard, but it also puts him in a new world with many dangers.
Director: Neil Burger | Stars: Bradley Cooper, Anna Friel, Abbie Cornish, Robert De Niro
Votes: 612,270 | Gross: $79.25M
5. The Fugitive (1993)
PG-13 | 130 min | Action, Crime, Drama
Dr. Richard Kimble, unjustly accused of murdering his wife, must find the real killer while being the target of a nationwide manhunt led by a seasoned U.S. Marshal.
Director: Andrew Davis | Stars: Harrison Ford, Tommy Lee Jones, Sela Ward, Julianne Moore
Votes: 318,577 | Gross: $183.88M
6. Awakenings (1990)
PG-13 | 121 min | Biography, Drama
The victims of an encephalitis epidemic many years ago have been catatonic ever since, but now a new drug offers the prospect of reviving them.
Director: Penny Marshall | Stars: Robert De Niro, Robin Williams, Julie Kavner, Ruth Nelson
Votes: 158,690 | Gross: $52.10M
7. A Nightmare on Elm Street 3: Dream Warriors (1987)
R | 96 min | Fantasy, Horror
A psychiatrist familiar with knife-wielding dream demon Freddy Krueger helps teens at a mental hospital battle the killer who is invading their dreams.
Director: Chuck Russell | Stars: Heather Langenkamp, Robert Englund, Craig Wasson, Patricia Arquette
Votes: 90,267 | Gross: $44.79M
8. Firestarter (1984)
R | 114 min | Action, Horror, Sci-Fi
A couple who participated in a potent medical experiment gain telepathic ability and then have a child who is pyrokinetic.
Director: Mark L. Lester | Stars: Drew Barrymore, David Keith, Freddie Jones, Heather Locklear
Votes: 36,894 | Gross: $15.10M
9. Limitless (2015–2016)
TV-14 | 42 min | Comedy, Crime, Drama
An average 28-year-old man who gains the ability to use the full extent of his brain's capabilities is hired by the F.B.I. as a consultant.
Stars: Jake McDorman, Jennifer Carpenter, Hill Harper, Mary Elizabeth Mastrantonio
Votes: 71,909
10. 3 Days to Kill (2014)
PG-13 | 117 min | Action, Drama, Thriller
A dying CIA agent trying to reconnect with his estranged daughter is offered an experimental drug that could save his life in exchange for one last assignment.
Director: McG | Stars: Kevin Costner, Hailee Steinfeld, Connie Nielsen, Amber Heard
Votes: 97,632 | Gross: $30.70M
11. The Bourne Legacy (2012)
PG-13 | 135 min | Action, Adventure, Thriller
An expansion of the universe from Robert Ludlum's novels, centered on a new hero whose stakes have been triggered by the events of the previous three films.
Director: Tony Gilroy | Stars: Jeremy Renner, Rachel Weisz, Edward Norton, Scott Glenn
Votes: 315,546 | Gross: $113.20M
12. Side Effects (I) (2013)
R | 106 min | Crime, Drama, Mystery
A young woman's world unravels when a drug prescribed by her psychiatrist has unexpected side effects.
Director: Steven Soderbergh | Stars: Rooney Mara, Channing Tatum, Jude Law, Catherine Zeta-Jones
Votes: 197,115 | Gross: $32.17M
13. Junior (1994)
PG-13 | 109 min | Comedy, Romance, Sci-Fi
As part of a fertility research project, a male scientist agrees to carry a pregnancy in his own body.
Director: Ivan Reitman | Stars: Arnold Schwarzenegger, Danny DeVito, Emma Thompson, Frank Langella
Votes: 72,982 | Gross: $36.76M
14. Max Payne (2008)
PG-13 | 100 min | Action, Crime, Drama
Coming together to solve a series of murders in New York City are a police detective and an assassin, who will be hunted by the police, the mob, and a ruthless corporation.
Director: John Moore | Stars: Mark Wahlberg, Mila Kunis, Beau Bridges, Ludacris
Votes: 130,169 | Gross: $40.69M
15. Funny People (2009)
R | 146 min | Comedy, Drama
When seasoned comedian George Simmons learns of his terminal, inoperable health condition, his desire to form a genuine friendship causes him to take a relatively green performer under his wing as his opening act.
Director: Judd Apatow | Stars: Adam Sandler, Seth Rogen, Leslie Mann, Eric Bana
Votes: 123,615 | Gross: $51.86M
16. The Haunting in Connecticut (2009)
PG-13 | 92 min | Drama, Horror, Mystery
After a family is forced to relocate for their son's health, they begin experiencing supernatural behavior in their new home, and uncover a sinister history.
Director: Peter Cornwell | Stars: Virginia Madsen, Martin Donovan, Elias Koteas, Kyle Gallner
Votes: 65,146 | Gross: $55.39M
17. Project Power (2020)
R | 113 min | Action, Crime, Sci-Fi
When a pill that gives its users unpredictable superpowers for five minutes hits the streets of New Orleans, a teenage dealer and a local cop must team with an ex-soldier to take down the group responsible for its creation.
Directors: Henry Joost, Ariel Schulman | Stars: Jamie Foxx, Joseph Gordon-Levitt, Dominique Fishback, Rodrigo Santoro
Votes: 97,712
18. Banshee Chapter (2013)
R | 87 min | Horror, Mystery, Sci-Fi
Journalist Anne Roland explores the disturbing links behind her friend's sudden disappearance, an ominous government research chemical, and a disturbing radio broadcast of unknown origin.
Director: Blair Erickson | Stars: Katia Winter, Ted Levine, Michael McMillian, Corey Moosa
Votes: 10,879
19. Silent Rage (1982)
R | 103 min | Action, Crime, Horror
A sheriff tries to stop the killing spree of a silent maniacal murderer who, as the result of secret genetic experimentation by an unethical scientist, has the ability to self-heal.
Director: Michael Miller | Stars: Chuck Norris, Ron Silver, Steven Keats, Toni Kalem
Votes: 6,700 | Gross: $10.49M
20. Jacob's Ladder (2019)
R | 89 min | Horror, Thriller
After his brother returns home from war, Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images.
Director: David M. Rosenthal | Stars: Michael Ealy, Jesse Williams, Nicole Beharie, Guy Burnet
Votes: 3,543
21. Comet (2014)
R | 91 min | Comedy, Drama, Romance
Set in a parallel universe, Comet bounces back and forth over the course of an unlikely but perfectly paired couple's six-year relationship.
Director: Sam Esmail | Stars: Justin Long, Emmy Rossum, Kayla Servi, Eric Winter
Votes: 19,651
22. Sisters (I) (2006)
R | 92 min | Crime, Horror, Mystery
A reporter witnesses a brutal murder and becomes entangled in a mystery involving a pair of Siamese twins who were separated at birth, one of them forced to live under the eye of a watchful, controlling psychiatrist.
Director: Douglas Buck | Stars: Chloë Sevigny, Stephen Rea, Lou Doillon, Dallas Roberts
Votes: 1,623
23. Go Goa Gone (2013)
Not Rated | 111 min | Action, Adventure, Comedy
A group of friends, just looking to have a good time in a rave party on a remote island in Goa, find out that the island is infested with Zombies.
Directors: Krishna D.K., Raj Nidimoru | Stars: Saif Ali Khan, Kunal Kemmu, Vir Das, Anand Tiwari
Votes: 15,299 | Gross: $0.30M
24. Backtrace (2018)
R | 92 min | Action, Crime, Drama
The lone surviving thief of a violent bank robbery is sprung from a high security facility and administered an experimental drug.
Director: Brian A. Miller | Stars: Ryan Guzman, Sylvester Stallone, Meadow Williams, Christopher McDonald
Votes: 5,348
25. Chillerama (2011)
Not Rated | 120 min | Action, Comedy, Horror
It's the closing night at the last drive-in theatre in America, and manager, Cecil Kaufman's planned to show 4 movies; films so rare, they've never been exhibited publicly on American soil, until tonight.
Directors: Adam Green, Joe Lynch, Bear McCreary, Adam Rifkin, Tim Sullivan | Stars: Adam Rifkin, Sarah Mutch, Ray Wise, Lin Shaye
Votes: 4,840
26. Unforgettable (1996)
R | 117 min | Drama, Mystery, Sci-Fi
A Seattle medical examiner uses an experimental memory transference drug to unravel the mystery surrounding his Wife's brutal murder.
Director: John Dahl | Stars: Ray Liotta, Linda Fiorentino, Peter Coyote, Christopher McDonald
Votes: 6,003 | Gross: $2.78M
27. Ritual (2002)
R | 99 min | Horror
An American nurse living in Jamaica grows suspicious of the nearby group of Voodoo practitioners.
Director: Avi Nesher | Stars: Jennifer Grey, Craig Sheffer, Daniel Lapaine, Kristen Wilson
Votes: 2,085
28. Bigger Than Life (1956)
Not Rated | 95 min | Drama
A seriously-ill schoolteacher becomes dependent on a "miracle" drug that begins to affect his sanity.
Director: Nicholas Ray | Stars: James Mason, Barbara Rush, Walter Matthau, Robert F. Simon
Votes: 8,145
29. The Facility (2012)
TV-MA | 80 min | Horror
Eight volunteers find themselves fighting for their lives when a drug trial goes horribly wrong.
Director: Ian Clark | Stars: Aneurin Barnard, Chris Larkin, Amit Shah, Alex Reid
Votes: 2,455
30. Tell Me How I Die (2016)
Not Rated | 107 min | Horror, Mystery, Thriller
A9913 is a new drug improving memory - like being there again. Anna joins 17 others testing it for $2000. Some experience the near future including deaths.
Director: D.J. Viola | Stars: Nathan Kress, Virginia Gardner, Kirby Bliss Blanton, Ryan Higa
Votes: 5,302
31. Higurashi: When They Cry - GOU (2020–2021)
TV-MA | Animation, Drama, Horror
Keiichi Maebara is in his new home in the peaceful Hinamizawa village, making friends with girls from school. He's here for a big festival. But something about this town seems off, with that fear what dark secrets can this small town hide?
Stars: Sôichirô Hoshi, Yukari Tamura, Mai Nakahara, Emi Lo
Votes: 776
32. Unstoppable (I) (2004)
R | 96 min | Action, Adventure, Drama
Dean has PTSD after a wet-job gone bad in Bosnia. Waiting for his police girlfriend at a diner, some bad guys inject him with a hallucinogen. It sends him back to traumatic experiences in Bosnia and he reacts violently.
Director: David Carson | Stars: Wesley Snipes, Jacqueline Obradors, Stuart Wilson, Kim Coates
Votes: 5,251
33. Horror High (1973)
PG | 85 min | Horror
A shock-filled tale of a serious and shy but brilliant science student who, when wrongfully forced to consume a new drug he'd created, becomes a modern day Jekyll and Hyde.
Director: Larry N. Stouffer | Stars: Pat Cardi, Austin Stoker, Rosie Holotik, John Niland
Votes: 1,177
34. Special (2006)
R | 81 min | Comedy, Drama, Sci-Fi
A lonely comic book fan, Les Franken, has a reaction to medication and becomes convinced he's a superhero.
Directors: Hal Haberman, Jeremy Passmore | Stars: Michael Rapaport, Paul Blackthorne, Josh Peck, Robert Baker
Votes: 5,910 | Gross: $0.01M
35. Dead Sushi (2012)
Not Rated | 92 min | Action, Comedy, Horror
Keiko, the daughter of a legendary sushi chef, runs away from home when his Karate-style regimen becomes too severe. Finding work at a rural hot springs inn, she is ridiculed by the eccentric staff and guests.
Director: Noboru Iguchi | Stars: Rina Takeda, Kentarô Shimazu, Takamasa Suga, Takashi Nishina
Votes: 1,808
36. We Were Here (I) (2011)
Not Rated | 90 min | Documentary, Biography, History
A deep and reflective look at the arrival and impact of AIDS in San Francisco and how individuals rose to the occasion during the first years of this unimaginable crisis.
Directors: David Weissman, Bill Weber | Stars: Ed Wolf, Daniel Goldstein, Guy Clark, Eileen Glutzer
Votes: 2,280
37. Shock Treatment (1964)
Approved | 94 min | Drama, Mystery, Thriller
An actor hired to locate $1 million in stolen loot endures the rigors of an insane asylum.
Director: Denis Sanders | Stars: Stuart Whitman, Carol Lynley, Roddy McDowall, Lauren Bacall
Votes: 613
38. Dr. Jekyll & Mistress Hyde (2003 Video)
Unrated | 88 min | Drama, Horror, Sci-Fi
Dr. Jackie Stevenson is a Los Angeles based therapist and scientist who tries to invent a serum to separate the pure from the lustful side of the female psychosis. After she has an ... See full summary »
Director: Tony Marsiglia | Stars: Julian Wells, Erin Brown, Ruby Larocca, Andrea Davis
Votes: 218
39. The Immaculate Conception of Little Dizzle (2009)
TV-MA | 104 min | Comedy, Drama
After he loses his high-paying job, Dory takes a gig as a night janitor in order to pay rent. Alone late at night inside a market research firm, he soon discovers the company is experimenting on their other janitors ...
Director: David Russo | Stars: Marshall Allman, Jeanette Maus, Sean Nelson, Allen Johnson
Votes: 1,011
40. Zombies! Zombies! Zombies! (2008 Video)
Not Rated | 82 min | Comedy, Horror
A drug experiment gone wrong produces a league of blood-thirsty zombies. It is up to a small band of exotic dancers trapped in a gentleman's club to fight back. Together they must rely on ... See full summary »
Director: Jason Murphy | Stars: Lyanna Tumaneng, Jessica Barton, Hollie Winnard, Sean Harriman
Votes: 2,453
41. Dead Don't Die in Dallas (2019)
Not Rated | 91 min | Action, Comedy, Horror
A miracle pill intended to save the world causes unforeseen side-effects forcing the surviving gays and bible thumpers in a small Texas town to join forces or fall prey to the flesh craving mutants.
Director: Israel Luna | Stars: Willam Belli, Richard D. Curtin, Krystal Summers, Dillon Vineyard
Votes: 293
42. The Darkroom (2006)
Not Rated | 83 min | Horror, Mystery, Thriller
A teenage boy befriends an escapee from a mental institution who sees visions of horrible murders being committed.
Director: Michael Hurst | Stars: Shawn Pyfrom, Reed Diamond, Greg Grunberg, Lucy Lawless
Votes: 1,021
43. Medicinen (2014)
114 min | Comedy, Drama
Johanna works as a jounalist on a womens magazine. But her boss is an idiot, her salary is ridiciolus and her husband has left her for a younger woman. With a great life crisis she decided to try a new medicine. She is not prepared for the results.
Director: Colin Nutley | Stars: Helena Bergström, Peter Eggers, Ida Engvoll, Katarina Ewerlöf
Votes: 1,250
44. Agent Beetle (2012)
80 min | Action
An undercover cop visits a drug company to get information on a program that gives convicted felons superpowers. With heat on his trail, he must use his newly acquired powers to stop the program and bring its powerful convicts to justice
Director: Brett Kelly | Stars: Emanuelle Carriere, Phil Dukarsky, Christine Emes, Celine Filion
Votes: 270
45. The Drug Trial: Emergency at the Hospital (2017 TV Movie)
58 min | Documentary, Drama
Docu-drama telling the story of one of the most infamous incidents in recent British medical history. On 13th March 2006, 8 healthy young men took part in a clinical trial for a leukaemia drug that went very wrong.
Director: Barbie MacLaurin | Stars: Philip Buck, Nadim Khan, Arun Daniel, Leo Hunter
Votes: 52
46. Operation Sandman (2000 TV Movie)
R | 91 min | Action, Drama, Sci-Fi
In the heat of an American desert, Captain Jean Farrell arrives at a secret military installation, run by the enigmatic Doctor Harlan Jessup. Jessup is conducting 'Operation Sandman', an ... See full summary »
Director: Nelson McCormick | Stars: Ron Perlman, Rod Biermann, Tony Devon, Bob Howard
Votes: 207
47. Painkiller (2013)
R | 80 min | Action, Mystery, Thriller
When an experimental lethal-injection has the unexpected result of making an inmate immortal, the most vicious convicts steal it to take over the prison and the world.
Director: Berenika Bailey | Stars: Mike Pfaff, Elodie Hara, Ron Pucillo, Carey Davis
Votes: 88
48. Little Blue Pill (2010)
Not Rated | 93 min | Comedy
A raucous comedy about an unlucky hipster who accidentally takes two Erectile Dysfunction pills and goes through a day of misadventures.
Director: Aaron Godfred | Stars: Aaron Kuban, Adam Carr, Rosie Tisch, Gerold Wunstel
Votes: 119
49. Life According to Sam (2013)
TV-G | 94 min | Documentary, Biography, Drama
A moving look at a couple's inspiring efforts to save their only son Sam from the rare and fatal premature-aging disease of progeria.
Directors: Sean Fine, Andrea Nix | Stars: Sam Berns, Leslie Gordon, Scott Berns, Francis Collins
Votes: 951
50. Hidden 3D (2011)
Not Rated | 81 min | Horror, Thriller
The scientist Susan Carter is researching the rehabilitation of addicts using an experimental drug in her rehab center. After her death, her idle son Brian Carter is forced by his friend ... See full summary »
Director: Antoine Thomas | Stars: Sean Clement, Simonetta Solder, Jordan Hayes, Jason Blicker
Votes: 1,878