The Lizard releases all reptiles in Central Park Zoo and decides to turn New York into a massive jungle to perfect his reptile army - Spider-Man has to stop him.
The Black Cat challenges Spider-Man, stating that she will steal the famous Maltese Mouse artifact. Spidey manages to stop the Cat and is offered to guard the artifact on live television - with the Black Cat about to strike again.
The Sandman steals radioactive soil samples from the NASA to make himself more powerful. Peter must expose his identity to the school board to safe face if he wishes to stay in college. But he must also stop the Sandman.
Communication satellites and power generators start to disappear, and Magneto broadcasts that he will return the satellites and power for a million dollars. Spider-Man travels to the Easter Island to face off against the super-villain.
Across New York, U.N. delegates are kidnapped and replaced by android duplicates. Meanwhile, in the distant kingdom of Latveria, the peasant Johan frees his father from captivity, vowing to also free his country from Doctor Doom.
Norman Osborn's memory of the Green Goblin is restored. He dons the mask of his evil Green Goblin persona and heads out to seek revenge against Spider-Man.
The leader of a burglary gang, called the Stuntman, offers to appear with Spider-Man on a TV show to pay damages caused by him but he actually wants revenge. Spider-Man must defeat the Stuntman on live television.
Dr. Doom battles Goron, a being that can shoot multi-property beams from his eyes. Doom proposes a partnership with Goron to take over the world. Spider-Man runs into Goron when Doom sends him to New York to uses his growth beams.
Peter's assignment from Jameson is to report on how valuables can be transported publicly be camouflage. The convoy is attacked by the Sidewinder. To get the property back, Spidey must defeat the Sidewinder's monstrous mechanical bull.
Jameson decides to hire Kraven the Hunter to capture the last known sabretooth tiger as a mascot for the Bugle which turns out to be Zabu. When Ka-Zar learns of Kraven's involvement in his pet's disappearance, he follows him to New York.
A new criminal, known as "the Gadgeteer", steals a shrinking ray. Attempting to stop him, Spider-Man is exposed to the device and swiftly begins shrinking in size.
Master criminal Professor Gizmo devises a plan to use Spider-Man to attach an antenna to a sunken treasure ship since only he can withstand the pressure at that depth. Peter has been invited to a charity cruise on board Jameson's yacht.