MacGyver is sent to Burma to retrieve a poison-filled canister from a crash site. While there, a drug lord mistakes MacGyver for a narcotics agent, forcing him into a confrontation.
MacGyver obtains a watch in Budapest that contains top secret information on microfilm. However, a young Gypsy girl steals the watch from MacGyver and he must get it back.
MacGyver is sent to Central America to rescue an American journalist and escape out of the country. The dictator of the country and his army pursue MacGyver, making the escape very difficult.
An American senator has $60 million in diamonds stolen from him by a Virgin Islands casino owner. MacGyver goes with the senator's daughter to steal the diamonds back from his high-security vault.
Deep in the Amazon jungle, a horde of killer ants is destroying everything in its path. MacGyver helps his entomologist friend and the plantation owner to battle the ants before the plantation is destroyed.
MacGyver is taken hostage by some armed robbers at an airport. MacGyver uses his ingenuity to try to free himself along with the other hostages while simultaneously trying to stop the criminals.
MacGyver visits some friends who are are drilling for oil. Their oil well catches fire and burns out of control. MacGyver is the only one who can stop the fire and save his friends' oil strike.
MacGyver is assigned to protect a person in the Federal Witness Protection Program. The man he is protecting wants to come out of hiding to visit his dying mother. MacGyver must protect him from the Mob and from the Feds.
There is a contract out on MacGyver so he leaves town and visits his Grandfather whom he hasn't seen in years. Soon the two are fighting for their lives in a cat and mouse hunt with the killers.