Jasmine battles her hangover in order to impress Ric. Zosia struggles to engage with a patient who reminds her of Arthur. Raf's hopes to progress his career are clouded.
Zosia strives to impress Tristan, but with her bipolar disorder affecting her health, she places herself and her patient in danger. Essie gets into trouble when she voices her concerns over a patient's teenage son.
Ric is suspended as a result of Jasmine's lies. Tristan is on the prowl. Hanssen pays the price when he takes over Jasmine's training. Serena struggles to hide her feelings from Bernie.
Raf is not convinced that Morven's motives are professional. Zosia warns Guy he is sealing a deal with the devil. Dominic tries to impress Isaac, but suffers the consequences.
Guy learns that Tristan and Jemima's relationship is far from perfect. Serena battles her feelings for Bernie by sleeping with an old friend. Ric is dealt an ultimatum which could destroy his reputation.
Guy is placed in an impossible situation. Raf continues to grow closer with Kim, but learns of her devastating diagnosis. Sacha is encouraged to sign-up to internet dating.
Isaac receives a research grant. Dom goes to extreme lengths to ensure his future with Isaac is secure. Inga is envious of Mo and Mr T. Bernie returns to Holby, leaving Serena torn.
Jac is unimpressed by the arrival of the new doctor Matteo Rossini. Cracks begin to show in Dom and Isaac's relationship. Bernie tries to keep her and Serena's relationship a secret.
Jac's test results leave Mr T concerned for her health. Raf treats Kim's son and is concerned by his welfare. Fletch bonds with a gambling addict, but not all is as it seems.
Essie takes action against a patient, forcing Sacha to step in and help her see sense. Ollie fights for Zosia when Matteo begins showing an interest in her. Morven finds herself getting close with Bernie's son.
Dom's plans for a perfect Christmas with Isaac are shattered. Jac pushes those who care about her away as she awaits news. Fletch is disheartened when he hears from his estranged father.
Jasmine is given one last chance at the hospital under Serena's leadership. Mo does whatever she can to suppress her feelings for Mr T as his wedding approaches. Essie and Raf argue over a patient.
Ollie must fight for Jac's support when Matteo pitches against him. Dom tries to keep his relationship with Isaac a secret from his parents. Cameron fights his feelings for Morven on his last shift.
Fletch's own fortunes take an unimaginable turn. Sacha suspects Essie and Raf are hiding their relationship from him. Matteo tries to win Jac over romantically.
Mo is forced to choose between Sweden and her profession. Dom is delighted when he learns he is going to Hawaii with Isaac, but he crushed when he discovers there's a catch. Fletch struggles to come to terms with his fate.
A familiar face returns to Holby as a patient. Jasmine feels the wrath of Serena's grief. Jac is determined to keep her and Matteo's relationship on the low.
Jac acknowledges her true feelings for Matteo. Bernie provides a shoulder for Serena to lean on. Raf is determined to keep his distance from Kim when she is readmitted to the hospital.
Isaac's paranoia over Dom leads him into danger. Mo and Mr T evaluate their childcare arrangements. Morven grows worried by Serena's abrasiveness towards Jasmine.
Raf is delighted by Kim's revelation, but his happiness is quickly dashed. Serena continues to intimidate Jasmine. Matteo hopes that he can learn more of Jac's personal life.
Jasmine's determination to prove herself to Jac and Serena comes at a cost. Essie worries for Kim's son. Ollie tries to convince himself he is no longer angry at Jac.
Dom attempts to cover for Isaac after accusations are made against him. Fletch makes a discovery about the man Morven has been messaging. Zosia's personal and professional lives collide.
Essie is put in an uncomfortable position. Zosia is determined to keep her secret from Ollie, unaware that Isaac knows. Serena helps Fletch cope with his adolescent daughter.
Dom is the victim of Isaac's violent outburst. Serena struggles with her grief when treating a patient who reminds her of her dead daughter. Ollie makes a decision about his and Zosia's future.
Dom is supported by the staff at Holby when Isaac's abusive streak is exposed. Fletch's positive attitude is dampened by an agency nurse. Matteo takes it upon himself to unite Jac and Jasmine.
Matteo is forced to face up to his past. Dom struggles to remain professional on his first day back at work. Bernie's son returns, providing Morven with a distraction.
Jac juggles the big reveal of her new project with the return of a familiar face as a patient. Ollie plans a big surprise for Zosia. A familiar agency nurse arrives at the hospital.
Lofty must confront his past. Mo unsuccessfully attempts to take on Jac's role. Jasmine worries after failing to recall the phone calls she made whilst she was drunk.
Mo and Mr T are left fearing for baby Hector's health. Nina is determined to keep a professional relationship with Matteo on her first day. Raf makes a startling discovery as Essie helps Dom form a team for the Holby half marathon.
Sacha is forced to take action against Dom's erratic behaviour. Fran is encouraged by Jasmine to seek support from Jac on her first day back. A new face sets foot on Darwin ward.
Mo questions how long she can continue working at Holby City. A family member of Ric's is admitted. Fran steps in as Jasmine and Jac's relationship continues to thaw.
Jasmine delves into Jac's past, unaware of the demons she is freeing for both Jac and Fran. Damon's first day is one he won't forget for a long time. Dom is left at odds with Lofty.
The staff at Holby City support each other in the aftermath of Jasmine's death. Jac is determined to not allow her feelings to weaken her superiority. Donna clashes with Fletch on her first day back.
Morven begins investigating Jasmine's death herself. Sacha treats a patient close to home. Damon suggests to Matteo that there is still hope for him and Nina.
Essie's private responsibilities clash with her professional ones. Bernie tasks Donna with keeping an eye on Morven. Jac is determined to get her job back on track.
Ollie grows weary of Guy's intentions. Sasha is given a prompt over his belief in God. Nina questions Matteo's feelings towards her following their return from an unromantic weekend away.
Zosia is given a rare opportunity to further her career, but it comes at a dear cost. Ollie struggles with the prospect of his ex-wife's death potentially being preventable. Lofty fears that Dom's not getting the message.
Events take a tragic turn at the Holby half-marathon. Lofty is forced to confront his true feelings towards Dom. Fletch enlists Jac's help when there is a shortage of theatre beds. Guy puts Zosia to the test.
Hanssen must confront a face from the past. Fredrik is determined to impress Sacha, Dom and Lofty. Guy's behaviour is a cause for concern for Zosia. Donna makes it her mission to teach Fletch a lesson.