In 1994, three little boys are murdered in a swimming pool, and everyone blames the two grunge kids from the low-class part of town. Years later, Rush reopens the case after one of the convicted kids takes his own life.
The detectives reopen the 2006 case of a murdered Jane Doe when relatives and friends identify her as an Amish teenager who went missing in Philadelphia during her Rumspringa.
The discovery of human remains in the bottom of a well leads to the reinvestigation of the case of a housewife who went missing during Orson Welles' radio broadcast of "War of the Worlds".
The discovery of a dead body in a storage facility reveals the presence of a serial killer who has killed four African-American boys over the course of a few years.
The 1960's case is reopened of a young girl named Samantha ("Sam") who was relentlessly teased and even groped at one point for dressing like a boy, after which she was found murdered and left in a river.
The 1940's case of a Japanese American killed after detainment in a camp is reopened. Meanwhile the Cold Case team fears their beloved boss, John Stillman, will retire and leave them.
The Cold Case team investigates a serial bomber who seems to be targeting people in no particular pattern, but then they discover the bomber may be killing out of grief and loss.
In 1962, a woman's death is ruled a suicide. Her granddaughter asks the team to investigate her suicide after she provides them with newer evidence she hopes will prove that her grandmother's suicide was actually a murder.