Sam emerges from his coma and discovers that he remembers nothing since losing his soul. Dean and Bobby try to keep the secret, and the brothers head to Oregon to investigate the disappearance of several local female virgins.
Sam has flashbacks of a case he worked with Samuel; Sam and Dean follow the coordinates received in a text message to a small town, where Sam used to live; townspeople's comments surprise Dean.
When Ben calls Dean and tells him that Lisa is in trouble, Dean leaves Sam to investigate a case alone and rushes to the rescue. However, he's not prepared for what meets him at the door.
To protect Sam and Dean from a surprise attack from Raphael, Balthazar sends them both into an alternate universe where their lives are a TV show called Supernatural (2005).
Dean, Sam, Castiel and Bobby find Eve in a small town where the citizens have been converted to demons; Eve decides to torture Sam and Dean by bringing their mother back as a demon.
Dean's worst nightmare comes true when a demon kidnaps Ben and Lisa in order to get to him. The brothers are forced to join forces with an unlikely ally to free them.
The wall comes down in Sam's head and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head.
Castiel believes he is the new God and becomes obsessed with power. Sam, Dean, and Bobby try to find a way to stop him before he explodes with power, even if that means talking to Death himself.
The leviathans destroy Castiel's body and break loose. Now Sam, Dean, and Bobby have to track them all down. Meanwhile, Sam is beginning to struggle with what is real and what is a hallucination.
An estranged Sam and Dean reunite to solve a curious case in the most psychic town in America, but it's far from happy families for the Winchester brothers.