Now that he has Sam in the cage with him, Lucifer offers Sam a way out but it comes with a steep price. Dean and Castiel look into the angel smiting that might have killed Amara.
Claire thinks recent murders in town are supernatural and asks Sam and Dean for help; Jody Mills reveals that Claire has been attacking people and accusing them of being monsters.
Sam and Dean investigate a set of murders on Valentine's Day and discover they are dealing with an ancient curse. Once kissed by the curse, the person is marked to die.
After dangerous creature is released into an old house, a mother and child are comatose. Sam and Dean find that Bobby and Rufus tracked the same creature so the Winchesters look to the past to catch the monster before any one dies.
In the midst of battling werewolves Sam gets shot then strangled and goes into shock. Dean, thinking Sam is actually dead, takes drastic measures to talk to a reaper in order to save his brother.
Sam and Dean are visiting a small town in Colorado where people are mysteriously disappearing every 27 years. While they are investigating, the boys encounter a pair of hunters seeking revenge on the monster causing the disappearances.
Amara unleashes a dark fog on a small town that causes everyone to go mad. Dean and Sam realize this is a stronger version of the original black vein virus Amara previously unleashed.
Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.
When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel's hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.
Sam and Dean investigate a case that leads them to a devout religious family living off the grid. They realize the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.
After learning that the soul of Adolf Hitler has been trapped in a 1930's gold pocket watch, Dean and Sam must act quickly to prevent a group of Nazi necromancers from resurrecting the Führer.
When hunters gather together to celebrate the life and tragic death of one of their own, Sam, Dean and Mary must take action when a demon starts picking off hunters one by one.
Lucifer realizes that as Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, he arranges a VIP concert in order to kill them. Sam, Dean and Castiel enter the underbelly of the music industry to stop him.