Dr Owens starts her internship with her friend Dr Will Collins. Alas her former high school nemesis Cassandra is also interning. The nurses don't like Emily, Cassandra shows her up, the resident doctor said she overstepped her bounds, etc.
Emily's cases include a man who is ineligible for surgery and will die without it; a woman who has an acute case of OCD and is difficult to diagnosis because of her compulsions. She tries to act normal around Will who rejected her love.
Dr Bandari quizzes the interns for the chance to help in surgery. While Cassandra wins, she freezes during the operation. Emily treats a gymnast with an unknown condition and a man who has gall bladder problems. Micah encourages Emily.
Emily and Micah help a patient who needs a kidney transplant, but does not want a kidney from her new husband. A woman pregnant with twins is a surrogate for her sister; one unborn twin is dying. Will wants to ask Cassandra out on a date.
Emily helps a patient who needs a partial liver transplant and a drug addict going through withdrawal. Micah asks Emily to be on the team helping with his mother's cancer treatment. Cassandra asks Emily to find out why Will is avoiding her.
Emily works with a well-known pediatrician on a baby diagnosed with male and female genitals. Tyra learns her father had an affair; she tells him she is a lesbian. Cassandra pretends to be friends with Emily for Will's sake but causes trouble.
It's Emily's birthday and she wants to keep it quiet. Will creates a party for her. Cases include a criminal in for a heart operation, and a loved flower delivery man who collapses during a delivery. Micah and Emily work together.