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MPAA Rated PG for bodily humor

Sex & Nudity

  • When Leah was in the hypothalamus the bottom of her butt is briefly seen
  • One of the animation scenes takes place in a nightclub, and shows several female characters scantily clad and acting/dressing promiscuously, one of them dancing erotically inside of a see-through tube, like that in a strip club
  • Osmosis asks what the uvula is and Drix says that is the thing that hangs in Frank's mouth. But before he says mouth Osmosis says boxer shorts.
  • Jones spots the shapely figure of a woman from behind and goes up to her, discovering her to be Leah. After he tries a pickup line on her, she smugly states that he looks like the kind of cell that would divide by himself (a possible sex/masturbation reference/joke or just a comment on him being a loner, etc.).
  • Lyrics in a song contain 1 use of "sex"
  • While the mayor is walking through the brain there is a plaque that says "our founder" and on top of it is a sperm cell.

Violence & Gore

  • Lots of gross out humor
  • A mafia germ named Scabies tells one his enforcers to remove Thrax and the big bruiser tries to throw a punch at him. Thrax, however, grabs him by the fist and then kicks him backwards. He then slices the Mafioso with his long, infected fingernail, cutting the older germ open, creating a festering wound that splits open and causes him to dissolve and then run down a drain.


  • In a deleted scene, Ozzy says "what the hell is a uvula?" In the final cut, "hell" is replaced with the non-profane "heck".
  • 1 use of damn

Alcohol, Drugs & Smoking

  • Frank asks if beer fluid, before drinking it when he feels ill
  • Uncle Bob smokes a cigar
  • A drug-related joke occurs in a lymph node precinct where a "cop" states that he caught a suspect with several grams of adrenaline, with the latter stating he's just holding it for his cousin.

Frightening & Intense Scenes

  • A zit pops and lands on a teacher's lip, it's very gross and they zoom in on the zit pulsating
  • A cleaning worker slowly looks for his partner who's suddenly disappeared (as some slightly suspenseful music plays) and then encounters Thrax (whose appearance might be scary to younger kids) who scratches him with his long fingernail, thus causing a wound on the worker that quickly boils over.


The Parents Guide items below may give away important plot points.

Violence & Gore

  • Thrax gets burned in the alcohol.

Frightening & Intense Scenes

  • Thrax enters a room Frank's subconscious. This might be too intense for some viewers.

See also

Taglines | Plot Summary | Synopsis | Plot Keywords

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