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Sex & Nudity
- It is implied that a dad rapes a baby.
- Several people are seen naked as victims; many explicit views of their butts. Breasts and vaginal areas are limited to partial or side views.
- A man masturbates with sandpaper around his penis.
- A woman is raped by a man who wraps his penis in barbed wire.
- A man and woman have sex in the front seat of a car for a few seconds.
- A prostitute briefly performs oral sex on a man; no nudity.
- A nude, pregnant woman gives birth.
- There are several references to a man being sexually abused by his father when he was younger. Voices of the father raping his son are heard through flashbacks.
Violence & Gore
- The girl at the front of the human centipede is failing to defecate properly, so a man force feeds her laxatives so the waste will be sloppy and watery. A disgusting sound is heard.
- A man shoots a young man in the foot (blood spurts from the wound and the man then hits the young man on the head with a crowbar, leaving his face soaked with blood).
- A man shoots a young woman in the leg (blood spurts from the wound) and then hits her on the head with a crowbar (leaving her face soaked in blood).
- A man is shown lying on the floor with a bloody wound in his stomach.
- A man approaches another man and a woman who are driving in their car with their young child and shoots at the windshield; the man falls out of the car with a bloody wound in his head and the other man hits him with a crowbar, knocking him unconscious (his face is left soaked in blood) and does the same to the man's pregnant wife as she tries to crawl away (blood pours down her face).
- A man grabs another man and pins him to a wall by his throat; he then throws the man to the floor and kicks him repeatedly in the stomach.
- A man grabs his mother by the back of the neck and forces her head inside a tank containing a centipede; it attacks and bites her face. He then hits his mother repeatedly on the head with a crowbar, completely crushing her skull. He then props her dead body up at a dinner table and her destroyed and gory face is seen.
- A man shoots another man in the leg (blood spurts and pours from the wound) and then hits him on the head with a crowbar (leaving his face soaked with blood).
- A man is shot in the shoulder (a bloody wound is shown) and hit on the head with a crowbar (his face is partly soaked in blood). A prostitute is then shot in the back. A man then approaches another man and shoots him in the penis (blood is shown) and the head (blood is shown).
- A man hits a woman on the head with a crowbar (blood spurts from the wound briefly and her face is partly soaked in blood).
- A man has five or six of his teeth smashed out (shown in close-up with very bloody results; the man chokes loudly as his mouth fills with blood).
- A woman's knee is cut open (the blade is shown cutting her flesh open in close-up with bloody results), reaches inside the wound and pulls out her ligament which he then cuts.
- A man uses a kitchen knife to cut open another man's knee (the blade is shown cutting his flesh open in close-up with very bloody results), reaches inside the wound and pulls out his ligament which he then cuts.
- A man's butt cheek is cut open and a piece of flesh pulled off (the man is shown to have died from this).
- A man uses a staple gun to staple another man's mouth to a woman's buttocks and does the same to other people (also shown in graphic close-up).
- A man violently rapes a woman from behind with barbed wire.
- A woman explosively defecates into another woman's mouth, and this continues as the waste goes through 12 people that are sewn together mouth-to-anus.
- A man uses a pair of pliers to pull out a woman's tongue (blood pours out of the woman's mouth and the severed tongue is shown).
- A woman defecates into a person's mouth; the woman at the end of the centipede then defecates onto the wall behind her.
- A woman goes into labor while running away; blood pours onto the floor. She then gets into a car and gives birth graphically; the woman then accidentally kills the baby by crushing its head underneath the gas pedal.
- A man tears stitches away from his mouth graphically; a large amount of blood pours from the man's mutilated mouth.
- Several people's throats are slit with a kitchen knife (blood spurts from the wounds).
- Several people are shot in the head (blood spurts from the wounds).
- A woman punches a man, pulls down his pants, puts a funnel into his anus and then puts a centipede into the funnel. The man then stabs the woman in the throat (blood briefly spurts).
- Uses of "fuck" and "cunt".
Alcohol, Drugs & Smoking
- A man is shown injecting victims with a laxative.
- A man smokes a cigarette.
Frightening & Intense Scenes
- The killing of the parents in front of a baby can be disturbing.
- The rating by today's standard is an NC-17
- Much more graphic, violent, and disgusting then the first film
- Suggested MPAA rating NC-17 for explicit content involving extreme violence and sexuality.
- The kidnapping, torture, and deaths of the victims may be disturbing for some viewers.
Sex & Nudity
- Many people are joined anus to mouth and graphic close-ups of the bare buttocks are thus shown. The same people also poop into each other's mouth and the process is shown in close up
Frightening & Intense Scenes
- There is a scene where a woman gives birth and squished the babies head with her foot. This scene is extremely disturbing and grotesque.