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Crypto is back with the Furons to take over in all parts of the world.


Tom Abernathy (head writer)

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Cast overview, first billed only:
J. Grant Albrecht ... Crypto (voice)
Richard Steven Horvitz ... Orthopox-13 / The Freak (voice)
Anthony Head ... Reginald Ponsonby-Smythe (voice) (as Anthony Stewart Head)
Courtenay Taylor ... Natalya Ivanova / Prudence Kane (voice)
Susanne Blakeslee ... Russian Women / Japanese Women (voice)
Jocelyn Blue Jocelyn Blue ... Japanese Co-Eds (voice)
Steve Blum ... Black Ninjas / Additional Voices (voice) (as Steven Blum)
Edita Brychta ... British Hippies / Additional Voices (voice)
Robin Atkin Downes ... Agent Oranchov / Hippies / Additional Voices (voice)
Keith Ferguson Keith Ferguson ... Bay City Cops / Bay City Soldiers (voice)
Jason Harris ... Astronaut "Biff" / American Men / Additional Voices (voice)
Yuri Lowenthal ... Englishmen / Astronaut 'Carl' / Additional Voices (voice)
Jim Meskimen ... Russian Men / Cosmonauts / Additional Voices (voice)
Phil Morris ... Gastro / Bay City Hippie / Bay City African-American Hippie (voice)
Paul Nakauchi ... Japanese Men / Ninjas / Additional Voices (voice)


Crypto is back with the Furons to take over in all parts of the world.

Plot Summary | Add Synopsis


Make war, not love.


T | See all certifications »

Parents Guide:

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Official Sites:

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Release Date:

17 October 2006 (USA) See more »

Also Known As:

Destroy All Humans! 2 See more »

Company Credits

Show more on IMDbPro »

Did You Know?


If you die in the game, the number of deaths will influence the last side mission in Takoshima, in which the "boss" will get as many lives as you have lost so far in the game. See more »


One of the White Ninjas' haiku makes reference to Angelina Jolie, even though, in the game's set year of 1969, she is not born yet. See more »


[first lines]
Ivan Oranchov: Premier comrade Milenkov, comrade agents, thank you for coming. Here's what we know so far.
[a slide show displaying the first game's events and its aftermath is shown]
Ivan Oranchov: Ten years ago, the United States government covered up an invasion by an alien race known as Furons. Their primary agent was this Furon: Cryptosporidium-137, dangerous, unpredictable and now deceased.
Milenkov: So? What is being problem?
Ivan Oranchov: The problem, comrade, is that Furons can clone themselves and pose convincingly as humans,...
See more »


References Teenage Mutant Ninja Turtles (1987) See more »

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User Reviews

A Great Sequel (God, did I just say that?)
28 December 2008 | by gruntspwnSee all my reviews

To put it simply, this is a fantastic game. Aside from some rather strong cussing, violence, and raunchy sexual innuendo, this may be my favorite game of all time. I was waiting for a game like this to be made. A game where you can play as the bad guy. For example, Resistance: Fall of Man was a great game. But I always hated the fact that you couldn't play from the Chimera's side and blow up humans. Playing the villain was even more refreshing than I expected. Richard Horvitz's performance as Orthropox 13 was perfect, as he has one of the best alien voices ever. Grant Albrecht was great as well, as his overbearing and rather loud voice adds to Cryptosporidium's character. I caution younger players, however, about the amount of violence, language, and sexual references in the game. That factor really turned me off. I give this game a 9/10.

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