Cast (in credits order)
| Kasie Hunt | ... | Self - Host | |
| Anthony Fauci | ... | Self (archive footage) (as Dr. Anthony Fauci) | |
| Donald Trump | ... | Self (archive footage) (as Trump) | |
| Jacqueline Alemany | ... | Self (as Jackie Alemany) | |
| Collin Morikawa | ... | Self (archive footage) | |
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Trey Mancini | ... | Self (archive footage) |
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Bill Karins | ... | Self |
| Jen Psaki | ... | Self (archive footage) | |
| Joe Biden | ... | Self (archive footage) (as President Joe Biden) | |
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Lisa Lerer | ... | Self |
| Tina Fey | ... | Self (archive footage) | |
| Amy Poehler | ... | Self (archive footage) | |
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Kate Rubins | ... | Self (archive footage) |
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Victor Glover | ... | Self (archive footage) |
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Bill Cassidy | ... | Self (archive footage) (as Sen. Bill Cassidy) |
| Carlos Curbelo | ... | Self (as Fmr. Rep. Carlos Curbelo) | |
| Hans Nichols | ... | Self | |
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Cedric Richmond | ... | Self (archive footage) (as Senator Richmond) |
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Mike Allen | ... | Self (archive footage) |
| Rest of cast listed alphabetically: | |||
| Dana Bash | ... | Self (archive footage) | |
| Chuck Todd | ... | Self (archive footage) | |