Deadly Fictional Diseases
by NDbportmanfan | created - 25 Jul 2017 | updated - 27 Jul 2017 | PublicWhich of the following diseases seen in either television, video games, or film would you say is the worst of the worst?
Discuss Here
- Instant Watch Options
- Genres
- Movies or TV
- IMDb Rating
- In Theaters
- Release Year
- Keywords
1. Rise of the Planet of the Apes (2011)
PG-13 | 105 min | Action, Drama, Sci-Fi
A substance designed to help the brain repair itself gives advanced intelligence to a chimpanzee who leads an ape uprising.
Director: Rupert Wyatt | Stars: James Franco, Andy Serkis, Freida Pinto, Karin Konoval
Votes: 559,771 | Gross: $176.76M
The Simian Flu
2. Game of Thrones (2011–2019)
TV-MA | 60 min | Action, Adventure, Drama
Nine noble families fight for control over the lands of Westeros, while an ancient enemy returns after being dormant for millennia.
Stars: Emilia Clarke, Peter Dinklage, Kit Harington, Lena Headey
Votes: 2,286,517
Greyscale
3. Batman & Robin (1997)
PG-13 | 125 min | Action, Sci-Fi
Batman and Robin try to keep their relationship together even as they must stop Mr. Freeze and Poison Ivy from freezing Gotham City.
Director: Joel Schumacher | Stars: Arnold Schwarzenegger, George Clooney, Chris O'Donnell, Uma Thurman
Votes: 268,215 | Gross: $107.33M
MacGregor's Syndrome
4. 28 Days Later (2002)
R | 113 min | Drama, Horror, Sci-Fi
Four weeks after a mysterious, incurable virus spreads throughout the UK, a handful of survivors try to find sanctuary.
Director: Danny Boyle | Stars: Cillian Murphy, Naomie Harris, Christopher Eccleston, Alex Palmer
Votes: 446,104 | Gross: $45.06M
Rage (Human Cortico-Deficiency Virus)
5. Osmosis Jones (2001)
PG | 95 min | Animation, Action, Adventure
A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Directors: Bobby Farrelly, Peter Farrelly | Stars: Laurence Fishburne, Chris Rock, David Hyde Pierce, Brandy Norwood
Votes: 38,775 | Gross: $13.60M
Red Death
6. Futurama (1999– )
TV-14 | 22 min | Animation, Adventure, Comedy
Philip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.
Stars: Billy West, John DiMaggio, Katey Sagal, Tress MacNeille
Votes: 261,103
Bone-itis
7. Cabin Fever (2002)
R | 93 min | Horror
Five college graduates rent a cabin in the woods and begin to fall victim to a horrifying flesh-eating virus, which attracts the unwanted attention of the homicidal locals.
Director: Eli Roth | Stars: Jordan Ladd, Rider Strong, James DeBello, Cerina Vincent
Votes: 83,726 | Gross: $21.16M
Flesh Eating Virus
8. Resident Evil (2002)
R | 100 min | Action, Horror, Sci-Fi
A special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.
Director: Paul W.S. Anderson | Stars: Milla Jovovich, Michelle Rodriguez, Ryan McCluskey, Oscar Pearce
Votes: 288,589 | Gross: $40.12M
T-Virus
9. Doctor Who (2005–2022)
TV-PG | 45 min | Adventure, Drama, Sci-Fi
The further adventures in time and space of the alien adventurer known as the Doctor and his companions from planet Earth.
Stars: Jodie Whittaker, Peter Capaldi, Pearl Mackie, Matt Smith
Votes: 246,678
Bliss Virus
10. Dragon Ball Z (1996–2003)
TV-PG | 24 min | Animation, Action, Adventure
With the help of the powerful Dragonballs, a team of fighters led by the saiyan warrior Goku defend the planet earth from extraterrestrial enemies.
Stars: Doc Harris, Christopher Sabat, Scott McNeil, Sean Schemmel
Votes: 147,919
Heart Virus
11. Supernatural (2005–2020)
TV-14 | 44 min | Drama, Fantasy, Horror
Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
Stars: Jared Padalecki, Jensen Ackles, Jim Beaver, Misha Collins
Votes: 483,473
Ghost Sickness
12. Blade Runner (1982)
R | 117 min | Action, Drama, Sci-Fi
A blade runner must pursue and terminate four replicants who stole a ship in space and have returned to Earth to find their creator.
Director: Ridley Scott | Stars: Harrison Ford, Rutger Hauer, Sean Young, Edward James Olmos
Votes: 823,463 | Gross: $32.87M
Methuselah Syndrome
13. Doomsday (I) (2008)
R | 105 min | Action, Sci-Fi, Thriller
A futuristic action thriller where a team of people work to prevent a disaster threatening the future of the human race.
Director: Neil Marshall | Stars: Rhona Mitra, Bob Hoskins, Alexander Siddig, Caryn Peterson
Votes: 79,951 | Gross: $10.96M
Reaper Virus
14. The Last of Us (2013 Video Game)
M | Action, Adventure, Drama
In a hostile, post-pandemic world, Joel and Ellie, brought together by desperate circumstances, must rely on each other to survive a brutal journey across what remains of the United States.
Directors: Neil Druckmann, Bruce Straley | Stars: Troy Baker, Ashley Johnson, Hana Hayes, Jeffrey Pierce
Votes: 76,161
Cordyceps Brain Infection
15. Contagion (2011)
PG-13 | 106 min | Drama, Thriller
Healthcare professionals, government officials and everyday people find themselves in the midst of a pandemic as the CDC works to find a cure.
Director: Steven Soderbergh | Stars: Matt Damon, Kate Winslet, Jude Law, Gwyneth Paltrow
Votes: 316,079 | Gross: $75.66M
MEV-1
16. The Andromeda Strain (1971)
G | 131 min | Mystery, Sci-Fi, Thriller
Top scientists work feverishly in a secret, state-of-the-art laboratory to discover what killed the citizens of a small town and how the deadly contagion can be stopped.
Director: Robert Wise | Stars: James Olson, Arthur Hill, David Wayne, Kate Reid
Votes: 40,464 | Gross: $3.42M
The Andromeda Strain
17. Halo: Combat Evolved (2001 Video Game)
M | Action, Adventure, Sci-Fi
Super-soldier John-117, Master Chief of the United Nations Space Command, must battle a genocidal alien race known as the Covenant following his violent crash-landing on Halo, an ancient and mysterious ring-world.
Director: Jason Jones | Stars: Jen Taylor, Pete Stacker, Tim Dadabo, Steve Downes
Votes: 12,172
Flood Parasite
18. Deus Ex (2000 Video Game)
M | Action, Adventure, Drama
In a dark cyberpunk future where poverty, disease, oppression and terrorism are widespread, J.C. Denton, a new cybernetically-enhanced special agent, finds evidence of a massive conspiracy when his brother, also an agent, goes rogue.
Director: Warren Spector | Stars: Jay Anthony Franke, Brent Anderson, Ralph Barbagallo, Chad Bannon
Votes: 3,436
Gray Death
19. Outbreak (1995)
R | 127 min | Action, Drama, Thriller
Army doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.
Director: Wolfgang Petersen | Stars: Dustin Hoffman, Rene Russo, Morgan Freeman, Kevin Spacey
Votes: 137,818 | Gross: $67.82M
Motaba
20. Mimic (1997)
R | 105 min | Horror, Sci-Fi
Three years ago, entomologist Dr. Susan Tyler genetically created an insect to kill cockroaches carrying a virulent disease. Now, the insects are out to destroy their only predator, mankind.
Director: Guillermo del Toro | Stars: Mira Sorvino, Jeremy Northam, Alexander Goodwin, Giancarlo Giannini
Votes: 55,696 | Gross: $25.48M
Strickler’s Disease
21. Dreamcatcher (2003)
R | 134 min | Drama, Horror, Sci-Fi
Friends on a camping trip discover that the town they're vacationing in is being plagued in an unusual fashion by parasitic aliens from outer space.
Director: Lawrence Kasdan | Stars: Morgan Freeman, Thomas Jane, Jason Lee, Damian Lewis
Votes: 96,488 | Gross: $33.72M
The Ripley
22. Gears of War (2006 Video Game)
M | Action, Sci-Fi, War
Mankind's desperate struggle for survival against a the Locust Horde, a nightmarish race of creatures that surface from the planet's core.
Director: Mo Davoudian | Stars: John DiMaggio, Carlos Ferro, Lester Speight, Fred Tatasciore
Votes: 9,254
Rust Lung
23. Carnosaur (1993)
R | 83 min | Horror, Sci-Fi
A genetically manipulated and very hungry dinosaur escapes from a bioengineering company and wreaks havoc on the local desert town. A security guard and a girl environmentalist try to stop both it and the company's doomsday bioweapon.
Directors: Adam Simon, Darren Patrick Moloney | Stars: Diane Ladd, Raphael Sbarge, Jennifer Runyon, Harrison Page
Votes: 4,363 | Gross: $1.75M
Carnosaur Virus
24. Johnny Mnemonic (1995)
R | 96 min | Action, Drama, Sci-Fi
A data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza.
Director: Robert Longo | Stars: Keanu Reeves, Dolph Lundgren, Dina Meyer, Ice-T
Votes: 76,219 | Gross: $19.08M
Nerve Attenuation Syndrome
25. Repo! The Genetic Opera (2008)
R | 98 min | Horror, Musical, Sci-Fi
A worldwide epidemic encourages a biotech company to launch an organ-financing program similar in nature to a standard car loan. The repossession clause is a killer, however.
Director: Darren Lynn Bousman | Stars: Paul Sorvino, Anthony Head, Alexa PenaVega, Sarah Brightman
Votes: 26,555 | Gross: $0.14M
Synaptic/Neuro Overstimulation Syndrome
26. Ultraviolet (2006)
PG-13 | 88 min | Action, Sci-Fi
A beautiful haemophage infected with a virus that gives her superhuman powers has to protect a boy in a futuristic world, who is thought to be carrying antigens that would destroy all hæmophages.
Director: Kurt Wimmer | Stars: Milla Jovovich, Cameron Bright, Nick Chinlund, Sebastien Andrieu
Votes: 84,106 | Gross: $18.50M
Hemoglophagia
27. The Walking Dead (2010–2022)
TV-MA | 45 min | Drama, Horror, Thriller
Sheriff Deputy Rick Grimes wakes up from a coma to learn the world is in ruins and must lead a group of survivors to stay alive.
Stars: Andrew Lincoln, Norman Reedus, Melissa McBride, Lauren Cohan
Votes: 1,082,895
TS-19
28. Fallout 3 (2008 Video Game)
M | Action, Adventure, Sci-Fi
Centuries following nuclear war, a teen leaves the safety of an underground vault in order to find their father, who left in hopes of creating a water purifier.
Director: Todd Howard | Stars: Liam Neeson, Malcolm McDowell, Ron Perlman, Odette Annable
Votes: 20,375
Forced Evolutionary Virus
29. Red Dwarf (1988– )
TV-14 | 30 min | Comedy, Sci-Fi
The adventures of the last human alive and his friends, stranded three million years into deep space on the mining ship Red Dwarf.
Stars: Chris Barrie, Craig Charles, Danny John-Jules, Robert Llewellyn
Votes: 37,309
Space Mumps
30. The Last Ship (2014–2018)
TV-14 | 60 min | Action, Drama, Sci-Fi
The crew of a naval destroyer is forced to confront the reality of a new existence when a pandemic kills off most of the earth's population.
Stars: Eric Dane, Adam Baldwin, Charles Parnell, Travis Van Winkle
Votes: 63,822
Red Flu
31. Babylon 5 (1993–1998)
TV-PG | 45 min | Action, Adventure, Drama
In the mid 23rd century, the Earth Alliance space station Babylon 5, located in neutral territory, is a major focal point for political intrigue, racial tensions and various wars over the course of five years.
Stars: Mira Furlan, Richard Biggs, Stephen Furst, Andreas Katsulas
Votes: 34,634
Drafa Plague
32. Firefly (2002–2003)
TV-14 | 45 min | Adventure, Drama, Sci-Fi
Five hundred years in the future, a renegade crew aboard a small spacecraft tries to survive as they travel the unknown parts of the galaxy and evade warring factions as well as authority agents out to get them.
Stars: Nathan Fillion, Gina Torres, Alan Tudyk, Morena Baccarin
Votes: 281,815
Bowden's Malady
33. Star Trek: The Next Generation (1987–1994)
TV-PG | 45 min | Action, Adventure, Drama
Set almost 100 years after Captain Kirk's 5-year mission, a new generation of Starfleet officers sets off in the U.S.S. Enterprise-D on its own mission to go where no one has gone before.
Stars: Patrick Stewart, Brent Spiner, Jonathan Frakes, LeVar Burton
Votes: 136,185
Barclay's Protomorphosis Syndrome
34. Dragon Age: Origins (2009 Video Game)
M | Action, Adventure, Fantasy
After four hundred years since the last Blight, a new Archdemon seeks to destroy the land of Ferelden. It is up to the player - as one of the remaining Grey Wardens - to unite the divided armies of Ferelden and save humanity.
Director: Dan Tudge | Stars: Steve Valentine, Peter Renaday, Kate Mulgrew, Tim Curry
Votes: 8,624
Blight Disease
35. The X-Files (1993–2018)
TV-14 | 45 min | Crime, Drama, Mystery
Two F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.
Stars: David Duchovny, Gillian Anderson, Mitch Pileggi, William B. Davis
Votes: 250,012
Purity
Tell Your Friends